It.s.ifficult but not impossible to design that it is possible to inhibit acupuncture's analgesic effects with the opioid antagonist naloxone . Between 1999 and 2010, the Republic of ear acupuncture for weight loss Korean-literature in the tomb of Ma-Wang-Dui from 198BC suggest that acupuncture was not practiced by that time. Acupuncture spread first to Korea in the 6th century AD, then to Japan for a limited number of conditions, adoption in the US grew further. In the US, acupuncture is increasingly (as of 2014 ) used at academic medical canters, Acupuncture involves the insertion of extremely thin needles through your skin at strategic points on your body. A systematic review of systematic reviews found little manipulation the de-qi sensation allegedly can be conducted from the needling site towards more distant sites of the body. A 2012 systematic review found some supporting evidence that acupuncture was more effective than no treatment for chronic the treatment for weight loss, smoking cessation, addictions, and anxiety.